Difference between revisions of "TrpA"
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]'' | + | * '''Operon:''' ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]-[[hisC]]-[[tyrA]]-[[aroE]]'' {{PubMed|3924737}} |
| − | * '''[[Sigma factor]]:''' [[SigA]] | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|6436812}} |
| − | * '''Regulation:''' induction by tryptophan ([[MtrB| TRAP]]) | + | * '''Regulation:''' |
| + | ** induction by tryptophan ([[MtrB| TRAP]]) {{PubMed|1551827}} | ||
| − | * '''Regulatory mechanism:''' [[MtrB| TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination | + | * '''Regulatory mechanism:''' |
| + | ** [[MtrB| TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination {{PubMed|8419914}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 19:36, 29 October 2009
- Description: tryptophan synthase (alpha subunit)
| Gene name | trpA |
| Synonyms | |
| Essential | no |
| Product | tryptophan synthase (alpha subunit) |
| Function | biosynthesis of tryptophan |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp | |
| MW, pI | 29 kDa, 4.817 |
| Gene length, protein length | 801 bp, 267 aa |
| Immediate neighbours | hisC, trpB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU22630
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O (according to Swiss-Prot)
- Protein family: UPF0403 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P07601
- KEGG entry: [3]
- E.C. number: 4.2.1.20
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
