Difference between revisions of "TrpC"
(→Expression and regulation) |
|||
| Line 92: | Line 92: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]'' | + | * '''Operon:''' ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]-[[hisC]]-[[tyrA]]-[[aroE]]'' {{PubMed|3924737}} |
| − | * '''[[Sigma factor]]:''' [[SigA]] | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|6436812}} |
| − | * '''Regulation:''' induction by tryptophan ([[MtrB| TRAP]]) | + | * '''Regulation:''' |
| + | ** induction by tryptophan ([[MtrB| TRAP]]) {{PubMed|1551827}} | ||
| − | * '''Regulatory mechanism:''' [[MtrB| TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination | + | * '''Regulatory mechanism:''' |
| + | ** [[MtrB| TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination {{PubMed|8419914}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 19:35, 29 October 2009
- Description: indole-3-glycerol-phosphate synthase
| Gene name | trpC |
| Synonyms | |
| Essential | no |
| Product | indole-3-glycerol-phosphate synthase |
| Function | biosynthesis of tryptophan |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp | |
| MW, pI | 27 kDa, 5.535 |
| Gene length, protein length | 750 bp, 250 aa |
| Immediate neighbours | trpF, trpD |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU22660
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P03964
- KEGG entry: [3]
- E.C. number: 4.1.1.48
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
