LiaR

• Description: two-component response regulator, regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin
  
  

Gene name	liaR
Synonyms	yvqC
Essential	no
Product	two-component response regulator
Function	regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin
MW, pI	22 kDa, 4.956
Gene length, protein length	633 bp, 211 aa
Immediate neighbours	gerAC, liaS
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU33080

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O32197

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: liaI-liaH-liaG-liaF-liaS-liaR

liaS-liaR

• Sigma factor: SigA

• Regulation: liaI: induced by bacitracin (LiaR)
  • repressed during logrithmic growth (AbrB) PubMed

liaS: constitutive

• Regulatory mechanism: LiaR: transcription activation
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant: HB0933 (aphA3), available in the Thorsten Mascher lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Thorsten Mascher, Karlsruhe Institute of Technology, Germany link