Difference between revisions of "MecA"
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| − | * '''Description:''' negative regulator of competence, targets ComK to | + | * '''Description:''' negative regulator of competence, targets [[ComK]] to [[ClpC]]-[[ClpP]] degradation machine (in log Phase) <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Product''' || adaptor protein | |style="background:#ABCDEF;" align="center"| '''Product''' || adaptor protein | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || control of ComK degradation, regulation of competence | + | |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[ComK]] degradation, regulation of competence |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 4.209 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 4.209 | ||
| Line 70: | Line 70: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[MecA]]-[[ComK]], [[MecA]]-[[ComS]], [[ClpC]]-[[MecA]] | + | * '''Interactions:''' [[MecA]]-[[ComK]] [http://www.ncbi.nlm.nih.gov/sites/entrez/10447896 PubMed] |
| + | , [[MecA]]-[[ComS]] [http://www.ncbi.nlm.nih.gov/sites/entrez/10447896 PubMed], [[ClpC]]-[[MecA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/10447896 PubMed] | ||
* '''Localization:''' | * '''Localization:''' | ||
Revision as of 14:17, 23 May 2009
- Description: negative regulator of competence, targets ComK to ClpC-ClpP degradation machine (in log Phase)
| Gene name | mecA |
| Synonyms | |
| Essential | no |
| Product | adaptor protein |
| Function | control of ComK degradation, regulation of competence |
| MW, pI | 25 kDa, 4.209 |
| Gene length, protein length | 654 bp, 218 aa |
| Immediate neighbours | yjbE, yjbF |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: mecA family (according to Swiss-Prot)
- Paralogous protein(s): YpbH
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
, MecA-ComS PubMed, ClpC-MecA PubMed
- Localization:
Database entries
- Structure:
- Swiss prot entry: P37958
- KEGG entry: BSU11520
- E.C. number:
Additional information
Expression and regulation
- Operon: mecA
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
