Difference between revisions of "LeuB"
| Line 82: | Line 82: | ||
* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P05645 P05645] | * '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P05645 P05645] | ||
| − | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU28270] | + | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU28270 BSU28270] |
* '''E.C. number:''' [http://www.expasy.org/enzyme/1.1.1.85 1.1.1.85] | * '''E.C. number:''' [http://www.expasy.org/enzyme/1.1.1.85 1.1.1.85] | ||
Revision as of 23:12, 13 May 2009
- Description: 3-isopropylmalate dehydrogenase
| Gene name | leuB |
| Synonyms | leuC |
| Essential | no |
| Product | 3-isopropylmalate dehydrogenase |
| Function | biosynthesis of leucine |
| MW, pI | 39 kDa, 4.744 |
| Gene length, protein length | 1095 bp, 365 aa |
| Immediate neighbours | leuC, leuA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure: 1XAD (Thermus thermophilus)
- Swiss prot entry: P05645
- KEGG entry: BSU28270
- E.C. number: 1.1.1.85
Additional information
Expression and regulation
- Regulation: repressed by casamino acids PubMed , expressed in the absence of branched-chain amino acids (BCAA), expression is stimulated in the presence of glucose PubMed, repressed by CodY PubMed
- Regulatory mechanism: CodY: transcription repression PubMed, glucose regulation: CcpA PubMed, repression by BCAA: tRNA-controlled RNA switch (T-box) that mediates termination/antitermination
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
