DivIC

• Description: cell-division initiation protein (septum formation), component of septosome (with DivIB)
  
  

Gene name	divIC
Synonyms
Essential	yes PubMed
Product	cell-division protein
Function	septum formation
Gene expression levels in SubtiExpress: divIC
Interactions involving this protein in SubtInteract: DivIC
MW, pI	14 kDa, 9.968
Gene length, protein length	375 bp, 125 aa
Immediate neighbours	yabQ, yabR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell division, sporulation proteins, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes, membrane proteins

This gene is a member of the following regulons

SigE regulon, SigM regulon, SigW regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU00620

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU00620

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: stabilizes FtsL against RasP cleavage PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • DivIC-FtsL PubMed
  • PbpB-DivIB-(FtsL-DivIC)2 PubMed, as part of the divisome

• Localization: membrane bound PubMed

Database entries

• BsubCyc: BSU00620

• Structure:

• UniProt: P37471

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • yabM-yabN-yabO-yabP-yabQ-divIC-yabR PubMed
  • yabP-yabQ-divIC-yabR PubMed
  • divIC-yabR PubMed

• Expression browser: divIC PubMed

• Sigma factor:
  • yabM: unknown
  • yabP: SigE PubMed
  • divIC: SigM PubMed, SigX PubMed, SigW PubMed

• Regulation: expressed during sporulation (SigE) PubMed and under stress conditions

• Regulatory mechanism:

• Additional information: there are about 50,000 molecules of DivIC per cell PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• FLAG-tag construct:
  • GP2006 divIC-3xFLAG ermC (based on pGP1087), available in Jörg Stülke's lab

• Antibody:

References

Additional publications: PubMed