Difference between revisions of "SppA"
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| − | * '''Description:''' signal peptide peptidase required for efficient processing of pre-proteins <br/><br/> | + | * '''Description:''' signal peptide peptidase required for efficient processing of pre-proteins, cleaves remnant signal peptides within the cellular membrane <br/><br/> |
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sppA_3020040_3021047_-1 sppA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sppA_3020040_3021047_-1 sppA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigW]] {{PubMed|9987136,12207695}} | + | * '''[[Sigma factor]]:''' [[SigW]] {{PubMed|9987136,12207695}} |
* '''Regulation:''' | * '''Regulation:''' | ||
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=References= | =References= | ||
| − | <pubmed>9987136,12207695 22472423 23980836 24228759 </pubmed> | + | <pubmed>9987136,12207695 22472423 23980836 24228759 24228759 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 14:26, 30 December 2013
- Description: signal peptide peptidase required for efficient processing of pre-proteins, cleaves remnant signal peptides within the cellular membrane
| Gene name | sppA |
| Synonyms | yteI |
| Essential | no |
| Product | signal peptide peptidase |
| Function | protein secretion |
| Gene expression levels in SubtiExpress: sppA | |
| Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
| MW, pI | 36 kDa, 7.314 |
| Gene length, protein length | 1005 bp, 335 aa |
| Immediate neighbours | yteJ, ytdI |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
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Contents
Categories containing this gene/protein
protein secretion, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU29530
Phenotypes of a mutant
- more sensitive to nisin PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- serine protease that functions to cleave the remnant signal peptides left behind after protein secretion and cleavage by signal peptidases
- Protein family: peptidase S49 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Interactions:
- the protein forms a dome shaped octameric complex PubMed
- Localization:
- cell membrane PubMed
Database entries
- UniProt: O34525
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
- self-processes its own C-termini PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
