Difference between revisions of "Smc"

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* '''Description:''' chromosome condensation and segregation SMC protein <br/><br/>
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* '''Description:''' part of the [[condensin]] complex, chromosomal origin condensation and segregation SMC protein <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Product''' || chromosome condensation and segregation SMC protein
 
|style="background:#ABCDEF;" align="center"| '''Product''' || chromosome condensation and segregation SMC protein
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"|'''Function''' || structural maintenance of the chromosome
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|style="background:#ABCDEF;" align="center"|'''Function''' || segregation of replication origins
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15940 smc]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15940 smc]
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
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* essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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* ''[[smc]]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth {{PubMed|24440399,24440393}}
  
 
=== Database entries ===
 
=== Database entries ===
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
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* '''Domains:'''  
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* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
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* '''Cofactor(s):'''
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* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
 
* '''[[SubtInteract|Interactions]]:'''  
 
* '''[[SubtInteract|Interactions]]:'''  
 +
** part of the [[condensin]] complex {{PubMed|24440399,24440393}}
 
** forms dimers {{PubMed|22385855}}
 
** forms dimers {{PubMed|22385855}}
 
** [[ScpA]]-[[Smc]] {{PubMed|12100548}}
 
** [[ScpA]]-[[Smc]] {{PubMed|12100548}}
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* '''[[Localization]]:'''
 
* '''[[Localization]]:'''
 
** nucleoid (heterogeneous) {{PubMed|16479537}}
 
** nucleoid (heterogeneous) {{PubMed|16479537}}
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** the ([[Smc]])2-[[ScpA]]-[[ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half {{PubMed|23475963}}
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** the [[condensin]] ([[Smc]])2-[[ScpA]]-[[ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [[Spo0J]] {{PubMed|24440393,23475963}}
  
 
=== Database entries ===
 
=== Database entries ===
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==Original publications==
 
==Original publications==
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<pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 22385855 23475963</pubmed>
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<pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 22385855 24440399,24440393 23475963</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 15:28, 16 February 2014

  • Description: part of the condensin complex, chromosomal origin condensation and segregation SMC protein

Gene name smc
Synonyms ylqA
Essential yes PubMed
Product chromosome condensation and segregation SMC protein
Function segregation of replication origins
Gene expression levels in SubtiExpress: smc
Interactions involving this protein in SubtInteract: Smc
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 135 kDa, 5.266
Gene length, protein length 3558 bp, 1186 aa
Immediate neighbours rnc, ftsY
Sequences Protein DNA DNA_with_flanks
Genetic context
Smc context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Smc expression.png















Categories containing this gene/protein

DNA condensation/ segregation, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU15940

Phenotypes of a mutant

  • essential PubMed
  • smc mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: SMC family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
    • 3ZGX (complex between the head domain of Smc (aa 1 - 219 and 983 - 1186) and the N-terminal winged-helix domain of ScpA) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews


Original publications

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