SipV

• Description: signal peptidase I
  
  

Gene name	sipV
Synonyms	yhjF
Essential	no
Product	signal peptidase I
Function	protein secretion
Gene expression levels in SubtiExpress: sipV
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	18 kDa, 10.121
Gene length, protein length	504 bp, 168 aa
Immediate neighbours	yhjE, yhjG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, membrane proteins

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

• Locus tag: BSU10490

Database entries

• BsubCyc: BSU10490

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)

• Protein family: peptidase S26 family (according to Swiss-Prot)

• Paralogous protein(s): SipS, SipT, SipU

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU10490

• Structure:

• UniProt: O07560

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yhjE-sipV (according to DBTBS)

• Expression browser: sipV PubMed

• Sigma factor:

• Regulation:
  • induced upon DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands

References

Reviews

Ross E Dalbey, Peng Wang, Jan Maarten van Dijl
Membrane proteases in the bacterial protein secretion and quality control pathway.
Microbiol Mol Biol Rev: 2012, 76(2);311-30
[PubMed:22688815] [WorldCat.org] [DOI] (I p)