Difference between revisions of "MsrB"
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|style="background:#ABCDEF;" align="center"|'''Function''' || regeneration of methionine and<br/> restoration of protein function after oxidative damage | |style="background:#ABCDEF;" align="center"|'''Function''' || regeneration of methionine and<br/> restoration of protein function after oxidative damage | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21680 msrB] |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 5.842 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 5.842 | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypqP]]'', ''[[msrA]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypqP]]'', ''[[msrA]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU21680 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU21680 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU21680 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:yppQ_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yppQ_context.gif]] | ||
Revision as of 13:05, 13 May 2013
- Description: peptide methionine sulfoxide reductase
| Gene name | msrB |
| Synonyms | yppQ |
| Essential | |
| Product | peptide methionine sulfoxide reductase |
| Function | regeneration of methionine and restoration of protein function after oxidative damage |
| Gene expression levels in SubtiExpress: msrB | |
| MW, pI | 16 kDa, 5.842 |
| Gene length, protein length | 429 bp, 143 aa |
| Immediate neighbours | ypqP, msrA |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
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Contents
Categories containing this gene/protein
resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU21680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 1XM0
- UniProt: P54155
- KEGG entry: [3]
- E.C. number: 1.8.4.12
Additional information
Expression and regulation
- Regulation: induced by oxidative stress (Spx)
- Regulatory mechanism: Spx: oxidized Spx binds RpoA and enhances msrA-msrB operon transcription PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
CongHui You, Agnieszka Sekowska, Olivera Francetic, Isabelle Martin-Verstraete, YiPing Wang, Antoine Danchin
Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis.
BMC Microbiol: 2008, 8;128
[PubMed:18662407]
[WorldCat.org]
[DOI]
(I e)
