KdgK

• Description: 2-dehydro-3-deoxygluconokinase
  
  

Gene name	kdgK
Synonyms
Essential	no
Product	2-dehydro-3-deoxygluconokinase
Function	utilization of galacturonic acid
Gene expression levels in SubtiExpress: kdgK
MW, pI	34 kDa, 5.681
Gene length, protein length	972 bp, 324 aa
Immediate neighbours	kdgA, kdgR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

CcpA regulon, KdgR regulon

The gene

Basic information

• Locus tag: BSU22110

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate (according to Swiss-Prot)

• Protein family: anti-sigma-factor antagonist family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P50845

• KEGG entry: [3]

• E.C. number: 2.7.1.45

Expression and regulation

• Operon: kdgR-kdgK-kdgA-kdgT PubMed

• Expression browser: kdgK PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by galacturonate (KdgR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • KdgR: transcription repression PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Petar Pujic, Rozenn Dervyn, Alexei Sorokin, S Dusko Ehrlich
The kdgRKAT operon of Bacillus subtilis: detection of the transcript and regulation by the kdgR and ccpA genes.
Microbiology (Reading): 1998, 144 ( Pt 11);3111-3118
[PubMed:9846747] [WorldCat.org] [DOI] (P p)