GtaB

• Description: UTP-glucose-1-phosphate uridylyltransferase, general stress protein
  
  

Gene name	gtaB
Synonyms
Essential	no
Product	UTP-glucose-1-phosphate uridylyltransferase
Function	biosynthesis of teichoic acid
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	32 kDa, 4.913
Gene length, protein length	876 bp, 292 aa
Immediate neighbours	mnaA, ggaB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell wall synthesis, lipid metabolism/ other, biosynthesis of cell wall components, general stress proteins (controlled by SigB), phosphoproteins

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU35670

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose (according to Swiss-Prot)

• Protein family: UDPGP type 2 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-76 PubMed
  • phosphorylated on ser/ thr/ tyr PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2E3D (from E. coli, 44% identity, 61% similarity) PubMed

• UniProt: Q05852

• KEGG entry: [3]

• E.C. number: 2.7.7.9

Expression and regulation

• Operon: gtaB PubMed

• Expression browser: gtaB PubMed

• Sigma factor: SigA PubMed, SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: