FbpA

• Description: Fur-regulated basic protein, acts as RNA chaperone for fsrA
  
  

Gene name	fbpA
Synonyms	ydbN
Essential	no
Product	Fur-regulated basic protein, acts as RNA chaperone for fsrA
Function	RNA chaperone
MW, pI	xx,x kDa, 9.50
Gene length, protein length	159 bp, 53 amino acids
Immediate neighbours	fbpB, ydbO
Gene sequence (+200bp)	Protein sequence
Genetic context

Categories containing this gene/protein

acquisition of iron, iron metabolism, RNA chaperones, short peptides

This gene is a member of the following regulons

Fur regulon

The gene

Basic information

• Locus tag:

Phenotypes of a mutant

• transcription profile of a fbpA fbpB double mutant strain: GEO PubMed

Database entries

• BsubCyc: ?

• DBTBS entry: no entry

• SubtiList entry: [1]

• GEO entry: GEO PubMed

Additional information

The sequence of the former ydbN gene was corrected, and does now contain two genes, fbpA and fbpB. PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: ?

• Structure:

• Swiss prot entry:

• KEGG entry: no entry

• E.C. number:

Expression and regulation

• Operon: fbpA-fbpB PubMed

• Sigma factor:

• Regulation:
  • induced upon iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Gregory T Smaldone, Olga Revelles, Ahmed Gaballa, Uwe Sauer, Haike Antelmann, John D Helmann
A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism.
J Bacteriol: 2012, 194(10);2594-605
[PubMed:22389480] [WorldCat.org] [DOI] (I p)

Ahmed Gaballa, Haike Antelmann, Claudio Aguilar, Sukhjit K Khakh, Kyung-Bok Song, Gregory T Smaldone, John D Helmann
The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins.
Proc Natl Acad Sci U S A: 2008, 105(33);11927-32
[PubMed:18697947] [WorldCat.org] [DOI] (I p)