Difference between revisions of "Ffh"
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| − | * '''Description:''' signal recognition particle (SRP) component <br/><br/> | + | * '''Description:''' [[signal recognition particle]] ([[SRP]]) component <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || signal recognition particle (SRP) component | + | |style="background:#ABCDEF;" align="center"| '''Product''' || [[signal recognition particle]] ([[SRP]]) component |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || presecretory protein translocation | |style="background:#ABCDEF;" align="center"|'''Function''' || presecretory protein translocation | ||
| Line 68: | Line 68: | ||
* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| − | * '''Protein family:''' GTP-binding SRP family (according to Swiss-Prot) | + | * '''Protein family:''' GTP-binding [[SRP]] family (according to Swiss-Prot) |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
| Line 86: | Line 86: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
** [[SecA]]-[[Ffh]] {{PubMed|9880811}} | ** [[SecA]]-[[Ffh]] {{PubMed|9880811}} | ||
| − | ** [[Ffh]]-[[Scr]] {{PubMed|21330537}} | + | ** [[Ffh]]-[[Scr]] in the [[signal recognition particle]] {{PubMed|21330537}} |
| − | ** [[Ffh]]-[[FtsY]] {{PubMed|21330537}} | + | ** [[Ffh]]-[[FtsY]] in the [[signal recognition particle]] {{PubMed|21330537}} |
* '''[[Localization]]:''' cell membrane (according to Swiss-Prot) | * '''[[Localization]]:''' cell membrane (according to Swiss-Prot) | ||
Revision as of 17:50, 30 November 2011
- Description: signal recognition particle (SRP) component
| Gene name | ffh |
| Synonyms | |
| Essential | yes PubMed |
| Product | signal recognition particle (SRP) component |
| Function | presecretory protein translocation |
| Interactions involving this protein in SubtInteract: Ffh | |
| Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
| MW, pI | 49 kDa, 9.422 |
| Gene length, protein length | 1338 bp, 446 aa |
| Immediate neighbours | ylxM, rpsP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
protein secretion, essential genes, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU15980
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: GTP-binding SRP family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- UniProt: P37105
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Sandro F Ataide, Nikolaus Schmitz, Kuang Shen, Ailong Ke, Shu-ou Shan, Jennifer A Doudna, Nenad Ban
The crystal structure of the signal recognition particle in complex with its receptor.
Science: 2011, 331(6019);881-6
[PubMed:21330537]
[WorldCat.org]
[DOI]
(I p)
Geeske Zanen, Haike Antelmann, Rob Meima, Jan D H Jongbloed, Marc Kolkman, Michael Hecker, Jan Maarten van Dijl, Wim J Quax
Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis.
Proteomics: 2006, 6(12);3636-48
[PubMed:16705751]
[WorldCat.org]
[DOI]
(P p)
K Bunai, K Yamada, K Hayashi, K Nakamura, K Yamane
Enhancing effect of Bacillus subtilis Ffh, a homologue of the SRP54 subunit of the mammalian signal recognition particle, on the binding of SecA to precursors of secretory proteins in vitro.
J Biochem: 1999, 125(1);151-9
[PubMed:9880811]
[WorldCat.org]
[DOI]
(P p)
H Takamatsu, K Bunai, T Horinaka, A Oguro, K Nakamura, K Watabe, K Yamane
Identification of a region required for binding to presecretory protein in Bacillus subtilis Ffh, a homologue of the 54-kDa subunit of mammalian signal recognition particle.
Eur J Biochem: 1997, 248(2);575-82
[PubMed:9346318]
[WorldCat.org]
[DOI]
(P p)
K Honda, K Nakamura, M Nishiguchi, K Yamane
Cloning and characterization of a Bacillus subtilis gene encoding a homolog of the 54-kilodalton subunit of mammalian signal recognition particle and Escherichia coli Ffh.
J Bacteriol: 1993, 175(15);4885-94
[PubMed:8335643]
[WorldCat.org]
[DOI]
(P p)
