GmuA

• Description: glucomannan-specific phosphotransferase system, EIIA component of the PTS
  
  

Gene name	gmuA
Synonyms	ydhN
Essential	no
Product	glucomannan-specific phosphotransferase system, EIIA component
Function	glucomannan uptake and phosphorylation
Interactions involving this protein in SubtInteract: GmuA
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	12 kDa, 5.63
Gene length, protein length	330 bp, 110 aa
Immediate neighbours	gmuB, gmuC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, phosphoproteins

This gene is a member of the following regulons

AbrB regulon, CcpA regulon, GmuR regulon

The gene

Basic information

• Locus tag: BSU05820

Expression

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: PTS permease, lactose permease (Lac) family PubMed

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: GmuA-HPr, GmuA-GmuB

• Localization:

Database entries

• Structure: 3K1S (IIA(Cel) from B. anthracis, 42% identity)

• UniProt: O05506

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: gmuB-gmuA-gmuC-gmuD-gmuR-gmuE-gmuF-gmuG PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by conjac glucomannan (requires GmuG) (GmuR) PubMed
  • induced by cellobiose (GmuR) PubMed
  • subject to carbon catabolite repression (CcpA) PubMed

• Regulatory mechanism:
  • GmuR: transcription repression PubMed
  • CcpA: transcription repression PubMed
  • AbrB: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed