Difference between revisions of "Sr1"
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| − | * '''Description:''' [[small RNAs|small regulatory RNA]] controlling [[ | + | * '''Description:''' [[small RNAs|small regulatory RNA]] controlling ''[[ahrC]]'' expression, peptide controlling the stability of the ''[[cggR]]-[[gapA]]'' mRNA <br/><br/> |
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= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
{{SubtiWiki regulon|[[CcpN regulon]]}} | {{SubtiWiki regulon|[[CcpN regulon]]}} | ||
| − | + | =The [[Sr1 regulon]]: ''[[ahrC]]''= | |
=The gene= | =The gene= | ||
Revision as of 12:19, 5 February 2011
- Description: small regulatory RNA controlling ahrC expression, peptide controlling the stability of the cggR-gapA mRNA
| Gene name | sr1 |
| Synonyms | ykzW |
| Essential | no |
| Product | small regulatory RNA/ regulatory peptide |
| Function | control of arginine metabolism and glycolysis |
| MW, pI | 4.4 kDa, 3.89 |
| Gene length, protein length | 205 bp (RNA), 120 bp (ORF), 39 aa |
| Immediate neighbours | slp, speA |
| Gene sequence | |
Genetic context 
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, utilization of amino acids, ncRNA
This gene is a member of the following regulons
The Sr1 regulon: ahrC
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
Additional information
Located between the slp and speA genes.
The RNA
Basic information/ Evolution
- Catalyzed reaction/ biological activity: hybridizes to ahrC mRNA and inhibits AhrC translation. PubMed
Extended information on the RNA
- Kinetic information
- Localization
Database entries
- Structure:
Additional information
Information on the structure of the RNA can be found in Heidrich et al., 2006
The peptide
Basic information/ Evolution
- Catalyzed reaction/ biological activity: the peptide controls the stability of the cggR-gapA mRNA PubMed
- Protein family: the peptide is conserved in bacilli
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure:
- UniProt: C0H410
- KEGG entry:
- E.C. number:
Additional information
Expression and regulation
- Operon: sr1 PubMed
- Regulatory mechanism: transcription repression PubMed
- Additional information:
Biological materials
- Mutant: 168 sr1::cat, available in Brantl lab
- Expression vector:
- lacZ fusion:
Labs working on this gene/protein
Sabine Brantl, Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany homepage
Your additional remarks
References
Matthias Gimpel, Nadja Heidrich, Ulrike Mäder, Hans Krügel, Sabine Brantl
A dual-function sRNA from B. subtilis: SR1 acts as a peptide encoding mRNA on the gapA operon.
Mol Microbiol: 2010, 76(4);990-1009
[PubMed:20444087]
[WorldCat.org]
[DOI]
(I p)
Nadja Heidrich, Isabella Moll, Sabine Brantl
In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA.
Nucleic Acids Res: 2007, 35(13);4331-46
[PubMed:17576690]
[WorldCat.org]
[DOI]
(I p)
Nadja Heidrich, Alberto Chinali, Ulf Gerth, Sabine Brantl
The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism.
Mol Microbiol: 2006, 62(2);520-36
[PubMed:17020585]
[WorldCat.org]
[DOI]
(P p)
Andreas Licht, Sven Preis, Sabine Brantl
Implication of CcpN in the regulation of a novel untranslated RNA (SR1) in Bacillus subtilis.
Mol Microbiol: 2005, 58(1);189-206
[PubMed:16164558]
[WorldCat.org]
[DOI]
(P p)
