SpoIVB

• Description: serine protease, cleaves SpoIVFA, this results in pro-SigK processing/activation in the mother-cell, does also cleave CtpB
  
  

Gene name	spoIVB
Synonyms
Essential	no
Product	serine protease
Function	control of SigK activation
MW, pI	45 kDa, 8.842
Gene length, protein length	1275 bp, 425 aa
Immediate neighbours	spo0A, recN
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

sigma factors and their control, sporulation proteins

This gene is a member of the following regulons

SigF regulon, SigG regulon

The gene

Basic information

• Locus tag: BSU24230

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Self-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the N-terminus of SpoIVB (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: SpoIVB-BofA PubMed, BofC-SpoIVB PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P17896

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIVB PubMed

• Sigma factor: SigF PubMed, SigG PubMed

• Regulation:
  • expressed during sporulation in the forespore (SigF, SigG, SpoVT) PubMed

• Regulatory mechanism:
  • SpoVT: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Simon Cutting, London, UK homepage