LiaR

• Description: two-component response regulator, regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin
  
  

Gene name	liaR
Synonyms	yvqC
Essential	no
Product	two-component response regulator
Function	regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin
MW, pI	22 kDa, 4.956
Gene length, protein length	633 bp, 211 aa
Immediate neighbours	gerAC, liaS
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU33080

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics, phosphoproteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on a Asp residue by LiaS

• Cofactor(s):

• Effectors of protein activity:

• Interactions: LiaS-LiaR

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O32197

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • liaI-liaH-liaG-liaF-liaS-liaR PubMed
  • liaG-liaF-liaS-liaR PubMed

• Sigma factor:
  • liaI: SigA PubMed
  • liaG: SigA PubMed

• Regulation:
  • liaI: induced by bacitracin (LiaR) PubMed
  • liaI:repressed during logarithmic growth (AbrB) PubMed
  • liaG: constitutive

• Regulatory mechanism:
  • LiaR: transcription activation PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage