DnaC

• Description: replicative DNA helicase, part of the replisome
  
  

Gene name	dnaC
Synonyms
Essential	yes PubMed
Product	replicative DNA helicase
Function	DNA replication
MW, pI	50 kDa, 4.548
Gene length, protein length	1362 bp, 454 aa
Immediate neighbours	yycE, yycD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU40440

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

DNA replication, essential genes

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: DnaB subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • DnaB-DnaC PubMed
  • DnaI-DnaC PubMed
  • part of the replisome: PolC-HolA-HolB-DnaX-DnaN-DnaG-DnaC-DnaI-DnaD-SsbA-DnaE-PriA-DnaB PubMed
  • YqaM-DnaC PubMed

• Localization: Cytoplasm (Homogeneous) PubMed

Database entries

• Structure: 2R6A (Geobacillus stearothermophilus), 2R6C, 2R6D, 2R6E

• UniProt: P37469

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: dnaC (according to DBTBS)

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: