Difference between revisions of "AccC"
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+ | = Categories containing this gene/protein = | ||
+ | {{SubtiWiki category|[[biosynthesis of lipids]]}}, | ||
+ | {{SubtiWiki category|[[essential genes]]}} | ||
=The protein= | =The protein= | ||
Revision as of 14:43, 30 November 2010
- Description: acetyl-CoA carboxylase (biotin carboxylase subunit)
Gene name | accC |
Synonyms | yqhX |
Essential | yes PubMed |
Product | acetyl-CoA carboxylase (biotin carboxylase subunit) |
Function | production of malonyl-CoA, the substrate for fatty acid biosynthesis |
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis | |
MW, pI | 49 kDa, 4.72 |
Gene length, protein length | 1350 bp, 450 aa |
Immediate neighbours | yqhY, accB |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU24340
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
Categories containing this gene/protein
biosynthesis of lipids, essential genes
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s): YotE
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- UniProt: P49787
- KEGG entry: [3]
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903]
[WorldCat.org]
[DOI]
(P p)
Original Publications