YwcE

• Description: holin, required for spore morphogenesis and germination
  
  

Gene name	ywcE
Synonyms	ipa-41r
Essential	no
Product	holin
Function	required for spore morphogenesis and germination
MW, pI	9 kDa, 9.845
Gene length, protein length	261 bp, 87 aa
Immediate neighbours	rodA, qoxD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU38130

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ywcE family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P39603

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ywcE PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during the log phase (AbrB), expressed only at the onset of stationary phase PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Charles Moran, Emory University, NC, USA homepage