Difference between revisions of "ComA"
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* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' phosphorylation activates DNA binding | + | * '''Effectors of protein activity:''' phosphorylation activates DNA binding, DNA-binding activity of ComA is inhibited by RapC {{PubMed|12950917}} and RapD {{PubMed|17227471}} |
| − | * '''Interactions:''' [[RapC]]-[[ComA]], [[ComP]]-[[ComA]] | + | * '''Interactions:''' [[RapC]]-[[ComA]] {{PubMed|12950917}}, [[ComP]]-[[ComA]] |
* '''Localization:''' cytoplasm (according to Swiss-Prot) | * '''Localization:''' cytoplasm (according to Swiss-Prot) | ||
| Line 118: | Line 118: | ||
=References= | =References= | ||
| − | <pubmed>11133937,2116363,12067344,8387999,19202088,10094672,8643670,11267663,16816200,10447896,12950917, 12270822 </pubmed> | + | <pubmed>17227471 11133937,2116363,12067344,8387999,19202088, 10094672,8643670,11267663, 16816200, 10447896,12950917, 12270822 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 08:07, 29 November 2009
- Description: two-component system response regulator, controls gene expression in response to cell density (concentration of ComX)
| Gene name | comA |
| Synonyms | srfB, comAA |
| Essential | no |
| Product | two-component system response regulator |
| Function | regulation of genetic competence and quorum sensing |
| MW, pI | 23 kDa, 4.759 |
| Gene length, protein length | 642 bp, 214 aa |
| Immediate neighbours | yuxO, comP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU31680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ComA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylated by ComP on an Asp residue
- Cofactor(s):
- Effectors of protein activity: phosphorylation activates DNA binding, DNA-binding activity of ComA is inhibited by RapC PubMed and RapD PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1U83
- UniProt: P14204
- KEGG entry: [3]
- E.C. number: 4.4.1.19
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
