Difference between revisions of "ManR"
| Line 68: | Line 68: | ||
* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' | + | * '''Modification:''' phosphorylation by [[ManP]] inactivates [[ManR]] (in the absence of mannose), phosphorylation by [[ptsH|HPr]] stimluates [[ManR]] {{PubMed|20139185}} |
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' |
| − | * '''Interactions:''' [[ManP]]-[[ManR]], [[ | + | * '''Interactions:''' [[ManP]]-[[ManR]], [[ptsH|HPr]]-[[ManR]], |
* '''Localization:''' | * '''Localization:''' | ||
| Line 91: | Line 91: | ||
=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[manR]]'' {{PubMed|20139185}} | ||
| − | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|20139185}} | |
| − | |||
| − | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced by mannose ([[ManR]]) {{PubMed|20139185}} | ||
| + | ** repressed by glucose ([[ManR]]) {{PubMed|20139185}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[ManR]]: transcription activation in the presence of mannose and absence of glucose {{PubMed|20139185}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 122: | Line 124: | ||
=References= | =References= | ||
| − | <pubmed>10627040 | + | <pubmed>10627040 20139185, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:32, 9 February 2010
| Gene name | manR |
| Synonyms | yjdC |
| Essential | no |
| Product | transcriptional activator, PRD-type |
| Function | regulation of mannose utilization |
| Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism | |
| MW, pI | 75 kDa, 8.04 |
| Gene length, protein length | 1944 bp, 648 aa |
| Immediate neighbours | yjdB, manP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU12000
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylation by ManP inactivates ManR (in the absence of mannose), phosphorylation by HPr stimluates ManR PubMed
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure:
- UniProt: O31644
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
