Difference between revisions of "FolC"
| Line 89: | Line 89: | ||
=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[valS]]-[[folC]]'' {{PubMed|9098041}} | ||
| − | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed9098041}} | |
| − | |||
| − | * '''[[Sigma factor]]:''' [[SigA]] | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced by valine limitation ([[T-box]]) {{PubMed9098041}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[T-box]]: [[riboswitch]], transcription termination/antitermination {{PubMed9098041}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 120: | Line 121: | ||
=References= | =References= | ||
| − | <pubmed>19258532,, </pubmed> | + | <pubmed>19258532,9098041, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:45, 13 December 2009
- Description: folyl-polyglutamate synthetase
| Gene name | folC |
| Synonyms | |
| Essential | no |
| Product | folyl-polyglutamate synthetase |
| Function | biosynthesis of folate |
| Metabolic function and regulation of this protein in SubtiPathways: tRNA charging, Folate | |
| MW, pI | 48 kDa, 5.806 |
| Gene length, protein length | 1290 bp, 430 aa |
| Immediate neighbours | comC, valS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU28080
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1) (according to Swiss-Prot)
- Protein family: folylpolyglutamate synthase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: Q05865
- KEGG entry: [3]
- E.C. number: 6.3.2.17
Additional information
Expression and regulation
- Regulation:
- induced by valine limitation (T-box) Template:PubMed9098041
- Regulatory mechanism:
- T-box: riboswitch, transcription termination/antitermination Template:PubMed9098041
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol Mol Biol Rev: 2009, 73(1);36-61
[PubMed:19258532]
[WorldCat.org]
[DOI]
(I p)
D Luo, J Leautey, M Grunberg-Manago, H Putzer
Structure and regulation of expression of the Bacillus subtilis valyl-tRNA synthetase gene.
J Bacteriol: 1997, 179(8);2472-8
[PubMed:9098041]
[WorldCat.org]
[DOI]
(P p)
