Difference between revisions of "FbpA"
| (21 intermediate revisions by 7 users not shown) | |||
| Line 1: | Line 1: | ||
| − | * '''Description:''' | + | * '''Description:''' Fur-regulated basic protein, acts as RNA chaperone for ''[[fsrA]]'' <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || Fur-regulated basic protein, <br/>acts as RNA chaperone for ''[[fsrA]]'' |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || RNA chaperone |
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=FbpA FbpA]''' | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || xx,x kDa, 9.50 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || xx,x kDa, 9.50 | ||
| Line 18: | Line 20: | ||
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 159 bp, 53 amino acids | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 159 bp, 53 amino acids | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ | + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[fbpB]]'', ''[[ydbO]]'' |
|- | |- | ||
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/genE_nucleotide.txt Gene sequence (+200bp) ]''' | |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/genE_nucleotide.txt Gene sequence (+200bp) ]''' | ||
| Line 24: | Line 26: | ||
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:FbpA_fbpB_context.jpeg]] | |colspan="2" | '''Genetic context''' <br/> [[Image:FbpA_fbpB_context.jpeg]] | ||
| + | |- | ||
| + | |colspan="2" |'''[http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=ydbN Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ydbN_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU04530]] | ||
|- | |- | ||
|} | |} | ||
| Line 29: | Line 33: | ||
__TOC__ | __TOC__ | ||
| − | <br/><br/> | + | <br/><br/><br/> |
| + | |||
| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[acquisition of iron]]}}, | ||
| + | {{SubtiWiki category|[[iron metabolism]]}}, | ||
| + | {{SubtiWiki category|[[RNA chaperones]]}}, | ||
| + | {{SubtiWiki category|[[short peptides]]}} | ||
| + | |||
| + | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[Fur regulon]]}} | ||
=The gene= | =The gene= | ||
| Line 35: | Line 48: | ||
=== Basic information === | === Basic information === | ||
| − | * ''' | + | * '''Locus tag:''' |
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * transcription profile of a ''[[fbpA]] [[fbpB]]'' double mutant strain: [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27416 GEO] {{PubMed|22389480}} | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12081] | * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12081] | ||
| + | |||
| + | * '''GEO entry:''' [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27416 GEO] {{PubMed|22389480}} | ||
=== Additional information=== | === Additional information=== | ||
The sequence of the former ydbN gene was corrected, and does now contain two genes, [[fbpA]] and [[fbpB]]. [http://www.ncbi.nlm.nih.gov/sites/entrez/18697947 PubMed] | The sequence of the former ydbN gene was corrected, and does now contain two genes, [[fbpA]] and [[fbpB]]. [http://www.ncbi.nlm.nih.gov/sites/entrez/18697947 PubMed] | ||
| + | |||
| + | |||
=The protein= | =The protein= | ||
| Line 76: | Line 96: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
* '''Structure:''' | * '''Structure:''' | ||
| Line 81: | Line 103: | ||
* '''Swiss prot entry:''' | * '''Swiss prot entry:''' | ||
| − | * '''KEGG entry:''' | + | * '''KEGG entry:''' no entry |
* '''E.C. number:''' | * '''E.C. number:''' | ||
| Line 88: | Line 110: | ||
=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[fbpA]]-[[fbpB]]'' {{PubMed|18697947}} | ||
| − | * ''' | + | * '''[[Sigma factor]]:''' |
| − | |||
| − | |||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced upon iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed] | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed] | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 119: | Line 142: | ||
=References= | =References= | ||
| − | + | <pubmed>18697947, 22389480 </pubmed> | |
| − | + | ||
| + | [[Category:short peptide]] | ||
Latest revision as of 10:41, 17 April 2014
- Description: Fur-regulated basic protein, acts as RNA chaperone for fsrA
| Gene name | fbpA |
| Synonyms | ydbN |
| Essential | no |
| Product | Fur-regulated basic protein, acts as RNA chaperone for fsrA |
| Function | RNA chaperone |
| Metabolic function and regulation of this protein in SubtiPathways: FbpA | |
| MW, pI | xx,x kDa, 9.50 |
| Gene length, protein length | 159 bp, 53 amino acids |
| Immediate neighbours | fbpB, ydbO |
| Gene sequence (+200bp) | Protein sequence |
Genetic context 
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
acquisition of iron, iron metabolism, RNA chaperones, short peptides
This gene is a member of the following regulons
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The sequence of the former ydbN gene was corrected, and does now contain two genes, fbpA and fbpB. PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry:
- KEGG entry: no entry
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Gregory T Smaldone, Olga Revelles, Ahmed Gaballa, Uwe Sauer, Haike Antelmann, John D Helmann
A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism.
J Bacteriol: 2012, 194(10);2594-605
[PubMed:22389480]
[WorldCat.org]
[DOI]
(I p)
Ahmed Gaballa, Haike Antelmann, Claudio Aguilar, Sukhjit K Khakh, Kyung-Bok Song, Gregory T Smaldone, John D Helmann
The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins.
Proc Natl Acad Sci U S A: 2008, 105(33);11927-32
[PubMed:18697947]
[WorldCat.org]
[DOI]
(I p)
