Difference between revisions of "FsrA"
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<br/><br/> | <br/><br/> | ||
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| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[carbon core metabolism]]}}, | ||
| + | {{SubtiWiki category|[[acquisition of iron]]}}, | ||
| + | {{SubtiWiki category|[[ncRNA]]}} | ||
| + | |||
| + | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[Fur regulon]]}} | ||
| + | =The [[FsrA regulon]]''= | ||
=The gene= | =The gene= | ||
| Line 32: | Line 41: | ||
=== Basic information === | === Basic information === | ||
| − | * ''' | + | * '''Locus tag:''' |
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * transcription profile of a ''[[fsrA]]'' mutant strain: [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27416 GEO] {{PubMed|22389480}} | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
| − | * '''DBTBS entry:''' | + | * '''DBTBS entry:''' no entry |
* '''SubtiList entry:''' no entry | * '''SubtiList entry:''' no entry | ||
| − | * '''Structure:''' | + | * '''GEO entry:''' [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27416 GEO] {{PubMed|22389480}} |
| + | |||
| + | * '''Structure:''' | ||
=== Additional information=== | === Additional information=== | ||
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* '''Swiss prot entry:''' | * '''Swiss prot entry:''' | ||
| − | * '''KEGG entry:''' | + | * '''KEGG entry:''' no entry |
| − | + | ||
* '''E.C. number:''' | * '''E.C. number:''' | ||
=== Additional information=== | === Additional information=== | ||
| + | |||
| + | |||
=The RNA= | =The RNA= | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' hybridizes to ''[[sdhC]]'' | + | * '''Catalyzed reaction/ biological activity:''' hybridizes to ''[[sdhC]], [[citB]], [[lutB]], [[gltA]]-[[gltB]]'', and ''[[leuC]]-[[leuD]]'' mRNAs and inhibits their translation. {{PubMed|18697947,22389480}} |
=== Extended information on the RNA=== | === Extended information on the RNA=== | ||
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* '''Kinetic information''' | * '''Kinetic information''' | ||
| − | * '''Interactions:''' Binds ''[[sdhC]]'' | + | * '''[[SubtInteract|Interactions]]:''' |
| + | ** Binds ''[[sdhC]], [[citB]], [[lutB]], [[gltA]]-[[gltB]]'', and ''[[leuC]]-[[leuD]]'' mRNAs {{PubMed|18697947,22389480}} | ||
| − | * '''Localization''' | + | * '''[[Localization]]''' |
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
* '''Structure''': | * '''Structure''': | ||
| Line 78: | Line 97: | ||
* '''Operon:''' | * '''Operon:''' | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' induced by iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/18697947 PubMed] | * '''Regulation:''' induced by iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/18697947 PubMed] | ||
| Line 95: | Line 114: | ||
=Labs working on this gene/RNA= | =Labs working on this gene/RNA= | ||
| + | |||
| + | [[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage] | ||
=Your additional remarks= | =Your additional remarks= | ||
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=References= | =References= | ||
| − | + | <pubmed>22427629,18697947,22389480</pubmed> | |
| − | + | ||
| + | [[Category:small RNA]] | ||
Latest revision as of 15:23, 2 April 2014
- Description: regulatory RNA
| Gene name | fsrA |
| Synonyms | |
| Essential | no |
| Product | sRNA FsrA |
| Function | inhibition of sdhC translation |
| Gene length | aaa bp |
| Immediate neighbours | ykuI, ykuJ |
| Gene sequence (+200bp) | |
Genetic context 
| |
Contents
Categories containing this gene/protein
carbon core metabolism, acquisition of iron, ncRNA
This gene is a member of the following regulons
The FsrA regulon
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: no entry
- Structure:
Additional information
- Swiss prot entry:
- KEGG entry: no entry
- E.C. number:
Additional information
The RNA
Basic information/ Evolution
- Catalyzed reaction/ biological activity: hybridizes to sdhC, citB, lutB, gltA-gltB, and leuC-leuD mRNAs and inhibits their translation. PubMed
Extended information on the RNA
- Kinetic information
Database entries
- Structure:
Additional information
Expression and regulation
- Operon:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
Labs working on this gene/RNA
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Gregory T Smaldone, Haike Antelmann, Ahmed Gaballa, John D Helmann
The FsrA sRNA and FbpB protein mediate the iron-dependent induction of the Bacillus subtilis lutABC iron-sulfur-containing oxidases.
J Bacteriol: 2012, 194(10);2586-93
[PubMed:22427629]
[WorldCat.org]
[DOI]
(I p)
Gregory T Smaldone, Olga Revelles, Ahmed Gaballa, Uwe Sauer, Haike Antelmann, John D Helmann
A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism.
J Bacteriol: 2012, 194(10);2594-605
[PubMed:22389480]
[WorldCat.org]
[DOI]
(I p)
Ahmed Gaballa, Haike Antelmann, Claudio Aguilar, Sukhjit K Khakh, Kyung-Bok Song, Gregory T Smaldone, John D Helmann
The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins.
Proc Natl Acad Sci U S A: 2008, 105(33);11927-32
[PubMed:18697947]
[WorldCat.org]
[DOI]
(I p)
