MecA

• Description: negative regulator of competence, targets ComK to ClpC-ClpP degradation machine (in log Phase)
  
  

Gene name	mecA
Synonyms
Essential	no
Product	adaptor protein
Function	control of ComK degradation, regulation of competence
MW, pI	25 kDa, 4.209
Gene length, protein length	654 bp, 218 aa
Immediate neighbours	yjbE, yjbF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: mecA family (according to Swiss-Prot)

• Paralogous protein(s): YpbH

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: MecA-ComK PubMed, MecA-ComS PubMed, ClpC-MecA PubMed

• Localization:

Database entries

• Structure:

• Swiss prot entry: P37958

• KEGG entry: BSU11520

• E.C. number:

Expression and regulation

• Operon: mecA

• Sigma factor: SigA

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed