Difference between revisions of "AlsS"
| Line 80: | Line 80: | ||
* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/Q04789 Q04789] | * '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/Q04789 Q04789] | ||
| − | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU36010] | + | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU36010 BSU36010] |
* '''E.C. number:''' [http://www.expasy.org/enzyme/2.2.1.6 2.2.1.6] | * '''E.C. number:''' [http://www.expasy.org/enzyme/2.2.1.6 2.2.1.6] | ||
Revision as of 21:52, 13 May 2009
- Description: acetolactate synthase
| Gene name | alsS |
| Synonyms | |
| Essential | no |
| Product | acetolactate synthase) |
| Function | overflow metabolism |
| MW, pI | 61 kDa, 5.164 |
| Gene length, protein length | 1713 bp, 571 aa |
| Immediate neighbours | alsD, alsR |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry: Q04789
- KEGG entry: BSU36010
- E.C. number: 2.2.1.6
Additional information
Expression and regulation
- Regulation: induction by acetate (AlsR) PubMed, repressed as long as terminal electron acceptors are available for respiration (Rex) PubMed
Note: since acetate formation requires ackA activation by CcpA there is an indirect effect of CcpA on the alsSD operon: the operon is not expressed in ccpA mutants
- Regulatory mechanism: AlsR: transcription activation in the presence of acetate PubMed, Rex: transcription repression if the ratio NADH2/NAD is high PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Renna, M. C., Najimudin, N., Winik, L. R., and Zahler, S. A. (1993). Regulation of the Bacillus subtilis alsS, alsD, and alsR genes involved in post-exponential-phase production of acetoin. J. Bacteriol. 175, 3863-3875. PubMed
- Reents, H., R. Münch, T. Dammeyer, D. Jahn, and E. Härtig. 2006. The Fnr regulon of Bacillus subtilis. J. Bacteriol. 188: 1103-1112. PubMed
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
