Difference between revisions of "ECF transporter"
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== The general components of the ECF transporters == | == The general components of the ECF transporters == | ||
* [[ybxA]] ATP-binding A1 protein (EcfA1) | * [[ybxA]] ATP-binding A1 protein (EcfA1) | ||
| + | * [[ybaE]] ATP-binding A2 protein (EcfA2) | ||
| + | * [[ybaF]] membrane-spanning T protein (EcfT) | ||
== The substrate-specific S components of the ECF transporters == | == The substrate-specific S components of the ECF transporters == | ||
| + | * [[RibU]]: uptake of riboflavin | ||
| + | * [[ThiT]]: uptake of thiamine | ||
| + | * [[YhfU]]: uptake of biotin | ||
| + | * [[TrpP]]: uptake of tryptophan | ||
| + | * [[YuiG]]: unknown specificity, may also transport biotin | ||
| + | * [[YpdP]]: queuosine precursor uptake | ||
| + | |||
| + | == The class I ECF transporter for thiamine == | ||
| + | * [[ThiU]]: binding protein | ||
| + | * [[ThiV]]: substrate-specific S component | ||
| + | * [[ThiW]]: ATP-binding protein (corresponds to A1 + A2) | ||
| + | * [[ThiX]]: membrane-spanning T protein | ||
== Important reviews and publications == | == Important reviews and publications == | ||
| − | <pubmed>23584589 , 21135102, 20497229, </pubmed> | + | <pubmed>23584589 , 21135102, 20497229, 18931129 22574898 24362466 27273632</pubmed> |
Latest revision as of 17:42, 26 March 2024
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Contents
ECF transporters are required for the uptake of micronutrients such as cofactors (vitamins), metal ions, or amino acids. The transporters are composed of three general components (membrane spanning T protein und two ATP-hydrolyzing A proteins) and substrate-specific S proteins.
In B. subtilis, there are four known substrates for ECF transporters, riboflavin, thiamine, biotin, and tryptophan.
The general components of the ECF transporters
- ybxA ATP-binding A1 protein (EcfA1)
- ybaE ATP-binding A2 protein (EcfA2)
- ybaF membrane-spanning T protein (EcfT)
The substrate-specific S components of the ECF transporters
- RibU: uptake of riboflavin
- ThiT: uptake of thiamine
- YhfU: uptake of biotin
- TrpP: uptake of tryptophan
- YuiG: unknown specificity, may also transport biotin
- YpdP: queuosine precursor uptake
The class I ECF transporter for thiamine
- ThiU: binding protein
- ThiV: substrate-specific S component
- ThiW: ATP-binding protein (corresponds to A1 + A2)
- ThiX: membrane-spanning T protein
Important reviews and publications
