ParC

• Description: subunit of DNA topoisomerase IV
  
  

Gene name	parC
Synonyms	grlA
Essential	yes PubMed
Product	subunit of DNA topoisomerase IV
Function	chromosome segregation and compaction
Gene expression levels in SubtiExpress: parC
MW, pI	91 kDa, 6.307
Gene length, protein length	2418 bp, 806 aa
Immediate neighbours	parE, ynfC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA condensation/ segregation, essential genes

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

• Locus tag: BSU18100

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU18100

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: topoisomerase gyrA/parC subunit family (according to Swiss-Prot)

• Paralogous protein(s): GyrA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (Homogeneous) PubMed
  • polar localization in actively growing cells PubMed

Database entries

• BsubCyc: BSU18100

• Structure: 1WP5 (C-terminal domain, Geobacillus stearothermophilus)

• UniProt: Q45066

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: parE-parC PubMed

• Expression browser: parC PubMed

• Sigma factor:

• Regulation:
  • induced by DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 67 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: