YhdL

• Description: anti-SigM protein
  
  

Gene name	yhdL
Synonyms
Essential	yes PubMed
Product	anti-SigM protein
Function	control of SigM activity
Gene expression levels in SubtiExpress: yhdL
Interactions involving this protein in SubtInteract: YhdL
MW, pI	40 kDa, 6.182
Gene length, protein length	1074 bp, 358 aa
Immediate neighbours	yhdK, sigM
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sigma factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes, membrane proteins

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

• Locus tag: BSU09510

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU09510

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SigM-YhdK-YhdL PubMed

• Localization: cell membrane PubMed

Database entries

• BsubCyc: BSU09510

• Structure:

• UniProt: O07581

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sigM-yhdL-yhdK PubMed

• Expression browser: yhdL PubMed

• Sigma factor: SigA PubMed, SigM PubMed

• Regulation:
  • induced by paraquat (SigM) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • BP97 (sigM-yhdL-yhdK::aphA3), available in Fabian Commichau's lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421] [WorldCat.org] [DOI] (P p)

Mika Yoshimura, Kei Asai, Yoshito Sadaie, Hirofumi Yoshikawa
Interaction of Bacillus subtilis extracytoplasmic function (ECF) sigma factors with the N-terminal regions of their potential anti-sigma factors.
Microbiology (Reading): 2004, 150(Pt 3);591-599
[PubMed:14993308] [WorldCat.org] [DOI] (P p)

M J Horsburgh, A Moir
Sigma M, an ECF RNA polymerase sigma factor of Bacillus subtilis 168, is essential for growth and survival in high concentrations of salt.
Mol Microbiol: 1999, 32(1);41-50
[PubMed:10216858] [WorldCat.org] [DOI] (P p)