YcnJ

• Description: copper transporter
  
  

Gene name	ycnJ
Synonyms
Essential	no
Product	copper transporter
Function	uptake of copper
Gene expression levels in SubtiExpress: ycnJ
MW, pI	59 kDa, 10.098
Gene length, protein length	1623 bp, 541 aa
Immediate neighbours	ycnI, ycnK
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins

This gene is a member of the following regulons

YcnK regulon

The gene

Basic information

• Locus tag: BSU03950

Phenotypes of a mutant

growth-defective under copper-limiting conditions PubMed

Database entries

• BsubCyc: BSU03950

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: uptake of copper PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane PubMed

Database entries

• BsubCyc: BSU03950

• Structure:

• UniProt: C0SP95

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ycnK-ycnJ-ycnI PubMed

• Expression browser: ycnJ PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by copper limitation (YcnK) PubMed
  • induction of the ycnK-ycnJ-ycnI in a csoR mutant results from intracellular copper depletion due to the constitutive expression of the copZ-copA operon (copper export) PubMed

• Regulatory mechanism:
  • YcnK: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage