Difference between revisions of "RpoC"
| Line 67: | Line 67: | ||
=== Additional information=== | === Additional information=== | ||
| − | + | * mutations in ''[[mtrB]]'', ''[[sigB]]'', ''[[rpoB]]'', and ''[[rpoC]]'' allow ''B. subtilis'' to grow with 4-fluorotryptophan rather than with tryptophan as a canonical amino acid of the genetic code {{PubMed|24572018}} | |
| − | |||
| − | |||
=The protein= | =The protein= | ||
| Line 85: | Line 83: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
** phosphorylated on Arg-335 and Arg-803 {{PubMed|22517742}} | ** phosphorylated on Arg-335 and Arg-803 {{PubMed|22517742}} | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| Line 158: | Line 156: | ||
<pubmed> 22210308 </pubmed> | <pubmed> 22210308 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | + | <pubmed>7657605,12486038,10675340,7592585, 19735077,18763711, 19680289 22517742 23070162,20817769 24572018</pubmed> | |
| − | <pubmed>7657605,12486038,10675340,7592585, 19735077,18763711, 19680289 22517742</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:22, 28 February 2014
- Description: RNA polymerase beta' subunit
| Gene name | rpoC |
| Synonyms | |
| Essential | yes PubMed |
| Product | RNA polymerase beta' subunit |
| Function | transcription |
| Gene expression levels in SubtiExpress: rpoC | |
| Interactions involving this protein in SubtInteract: RpoC | |
| MW, pI | 133 kDa, 8.863 |
| Gene length, protein length | 3597 bp, 1199 aa |
| Immediate neighbours | rpoB, ybxF |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transcription, essential genes, membrane proteins, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU01080
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
- mutations in mtrB, sigB, rpoB, and rpoC allow B. subtilis to grow with 4-fluorotryptophan rather than with tryptophan as a canonical amino acid of the genetic code PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1) (according to Swiss-Prot)
- Protein family: RNA polymerase beta' chain family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- phosphorylated on Arg-335 and Arg-803 PubMed
- Effectors of protein activity:
- Interactions:
- RpoA-RpoB-RpoC PubMed
- SigA-(RpoB-RpoC) PubMed, SigB-(RpoB-RpoC)
- SigD-(RpoB-RpoC), SigE-(RpoB-RpoC)
- SigF-(RpoB-RpoC), SigG-(RpoB-RpoC)
- SigH-(RpoB-RpoC), SigI-(RpoB-RpoC)
- SigK-(RpoB-RpoC), SigL-(RpoB-RpoC)
- SigM-(RpoB-RpoC), SigV-(RpoB-RpoC)
- SigW-(RpoB-RpoC), SigX-(RpoB-RpoC)
- SigY-(RpoB-RpoC), SigZ-(RpoB-RpoC)
- Xpf-(RpoB-RpoC), YlaC-(RpoB-RpoC)
- YvrHa-RpoC PubMed
- Localization: membrane associated PubMed
Database entries
- Structure:
- UniProt: P37871
- KEGG entry: [2]
- E.C. number: 2.7.7.6
Additional information
Expression and regulation
- Operon:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Lakshminarayan M Iyer, L Aravind
Insights from the architecture of the bacterial transcription apparatus.
J Struct Biol: 2012, 179(3);299-319
[PubMed:22210308]
[WorldCat.org]
[DOI]
(I p)
Original publications
