Difference between revisions of "PlsX"
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| − | * '''Description:''' acyl-acyl carrier protein (ACP):phosphate acyltransferase, catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4) <br/><br/> | + | * '''Description:''' acyl-acyl carrier protein (ACP):phosphate acyltransferase, catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4), coordinates membrane synthesis with [[cell division]] <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ylpD '' | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ylpD '' | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Essential''' || yes | + | |style="background:#ABCDEF;" align="center"| '''Essential''' || yes {{PubMed|24224907,12682299}} |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Product''' || acyl-acyl carrier protein (ACP):phosphate acyltransferase | |style="background:#ABCDEF;" align="center"| '''Product''' || acyl-acyl carrier protein (ACP):phosphate acyltransferase | ||
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<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
| − | + | <br/><br/> | |
| − | |||
| − | |||
| − | |||
| − | |||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[cell division]]}}, | ||
{{SubtiWiki category|[[biosynthesis of lipids]]}}, | {{SubtiWiki category|[[biosynthesis of lipids]]}}, | ||
{{SubtiWiki category|[[essential genes]]}} | {{SubtiWiki category|[[essential genes]]}} | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | ** essential | + | ** essential {{PubMed|24224907,12682299}} |
** depletion results in sporulation deficiency (via [[SpoIIR]]) {{PubMed|22111992}} | ** depletion results in sporulation deficiency (via [[SpoIIR]]) {{PubMed|22111992}} | ||
| + | ** a ts mutant forms an abberant Z-ring and has a [[cell division]] defect {{PubMed|24224907}} | ||
| + | |||
=== Database entries === | === Database entries === | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** [[PlsX]]-[[PlsY]] | + | ** [[PlsX]]-[[PlsY]] {{PubMed|19282621}} |
| + | ** [[PlsX]]-[[FtsA]] {{PubMed|24224907}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
| + | ** localizes to the cell division sites, colocalizes with the Z-ring {{PubMed|24224907}} | ||
=== Database entries === | === Database entries === | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=plsX_1662547_1663548_1 plsX] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=plsX_1662547_1663548_1 plsX] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigA]] {{PubMed|16932747}} | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|16932747}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| Line 149: | Line 150: | ||
=References= | =References= | ||
| − | + | <pubmed>12737802, 19282621, 17645809, 17557823, 8759840 16932747 19850612 16091051 21383089 22111992 24224907</pubmed> | |
| − | <pubmed>12737802, 19282621, 17645809, 17557823, 8759840 16932747 19850612 16091051 21383089</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:18, 12 January 2014
- Description: acyl-acyl carrier protein (ACP):phosphate acyltransferase, catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4), coordinates membrane synthesis with cell division
| Gene name | plsX |
| Synonyms | ylpD |
| Essential | yes PubMed |
| Product | acyl-acyl carrier protein (ACP):phosphate acyltransferase |
| Function | biosynthesis of phospholipids |
| Gene expression levels in SubtiExpress: plsX | |
| Interactions involving this protein in SubtInteract: PlsX | |
| Metabolic function and regulation of this protein in SubtiPathways: plsX | |
| MW, pI | 35 kDa, 5.492 |
| Gene length, protein length | 999 bp, 333 aa |
| Immediate neighbours | fapR, fabD |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell division, biosynthesis of lipids, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU15890
Phenotypes of a mutant
- essential PubMed
- depletion results in sporulation deficiency (via SpoIIR) PubMed
- a ts mutant forms an abberant Z-ring and has a cell division defect PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)
- Protein family: plsX family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Localization:
- localizes to the cell division sites, colocalizes with the Z-ring PubMed
Database entries
- Structure: 1VI1
- UniProt: P71018
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Matsumoto lab PubMed
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
