Difference between revisions of "OdhA"
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
** phosphorylated on Arg-66 and Arg-621 {{PubMed|22517742}} | ** phosphorylated on Arg-66 and Arg-621 {{PubMed|22517742}} | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=odhA_2108774_2111608_-1 odhA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=odhA_2108774_2111608_-1 odhA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigA]] {{PubMed|1508153}} | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|1508153}} |
* '''Regulation:''' | * '''Regulation:''' | ||
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<pubmed> 10672230</pubmed> | <pubmed> 10672230</pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>2500417,20933603,1508153, 11976317 12850135 22517742 22900538 </pubmed> | + | <pubmed>2500417,20933603,1508153, 11976317 12850135 22517742 22900538 24263382 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:54, 17 December 2013
- Description: 2-oxoglutarate dehydrogenase (E1 subunit)
| Gene name | odhA |
| Synonyms | citK |
| Essential | no |
| Product | 2-oxoglutarate dehydrogenase (E1 subunit) |
| Function | TCA cycle |
| Gene expression levels in SubtiExpress: odhA | |
| Interactions involving this protein in SubtInteract: OdhA | |
| Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism | |
| MW, pI | 105 kDa, 5.871 |
| Gene length, protein length | 2823 bp, 941 aa |
| Immediate neighbours | odhB, yojO |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
carbon core metabolism, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU19370
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 (according to Swiss-Prot)
- Protein family: 2-oxoacid dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- phosphorylated on Arg-66 and Arg-621 PubMed
- Effectors of protein activity:
Database entries
- UniProt: P23129
- KEGG entry: [3]
- E.C. number: 1.2.4.2
Additional information
- extensive information on the structure and enzymatic properties of 2-oxoglutarate dehydrogenase can be found at Proteopedia
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- GP671 (spc), GP684 (cat), GP1274 (cat) available in Jörg Stülke's lab
- GP1276 (odhA-odhB::cat), available in Jörg Stülke's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
K F Sheu, J P Blass
The alpha-ketoglutarate dehydrogenase complex.
Ann N Y Acad Sci: 1999, 893;61-78
[PubMed:10672230]
[WorldCat.org]
[DOI]
(P p)
Original publications
