Difference between revisions of "DegS"
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * the mutation suppresses the mucoid phenotype of ''[[motA]]'' or ''[[motB]]'' mutants due to loss of [[DegU]] phosphorylation and concomitant reduced expression of the ''[[pgsB]]-[[pgsC]]-[[pgsA]]'' operon {{PubMed|24296669}} | ||
=== Database entries === | === Database entries === | ||
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=== Additional information=== | === Additional information=== | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' autophosphorylation, autodephosphorylation, phosphorylation of [[DegU]] on Asp-56 [http://www.ncbi.nlm.nih.gov/sites/entrez/1901568 PubMed] | + | * '''Catalyzed reaction/ biological activity:''' |
| + | ** autophosphorylation, autodephosphorylation, phosphorylation of [[DegU]] on Asp-56 [http://www.ncbi.nlm.nih.gov/sites/entrez/1901568 PubMed] | ||
* '''Protein family:''' | * '''Protein family:''' | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
** aa 12 ... 170: unknown DegS domain | ** aa 12 ... 170: unknown DegS domain | ||
** aa 180 ... 248: HisKA_3 domain (autophosphorylation) | ** aa 180 ... 248: HisKA_3 domain (autophosphorylation) | ||
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** autophosphorylation on His-189 | ** autophosphorylation on His-189 | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' [[DegQ]] (stimulation of autophosphorylation) {{PubMed|21965392}} | * '''Effectors of protein activity:''' [[DegQ]] (stimulation of autophosphorylation) {{PubMed|21965392}} | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=degS_3645379_3646536_-1 degS] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=degS_3645379_3646536_-1 degS] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigA]] {{PubMed|1688843}} | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|1688843}} |
* '''Regulation:''' | * '''Regulation:''' | ||
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<pubmed>23927648 </pubmed> | <pubmed>23927648 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>17850253,12471443,14563871,1459944,1901568,10094672,1688843 ,16479537, 17218307 21304896 21965392</pubmed> | + | <pubmed>17850253,12471443,14563871,1459944,1901568,10094672,1688843 ,16479537, 17218307 21304896 21965392 24296669</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:04, 4 December 2013
- Description: two-component sensor kinase for exoenzyme and competence regulation
| Gene name | degS |
| Synonyms | sacU |
| Essential | no |
| Product | two-component sensor kinase |
| Function | regulation of degradative enzyme and genetic competence |
| Gene expression levels in SubtiExpress: degS | |
| Interactions involving this protein in SubtInteract: DegS | |
| MW, pI | 44 kDa, 5.988 |
| Gene length, protein length | 1155 bp, 385 aa |
| Immediate neighbours | degU, yvyE |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
protein modification, transcription factors and their control, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU35500
Phenotypes of a mutant
- the mutation suppresses the mucoid phenotype of motA or motB mutants due to loss of DegU phosphorylation and concomitant reduced expression of the pgsB-pgsC-pgsA operon PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- aa 12 ... 170: unknown DegS domain
- aa 180 ... 248: HisKA_3 domain (autophosphorylation)
- aa 289 ... 384: HATPase_c
- Modification:
- Localization: Cytoplasm (Homogeneous) PubMed
Database entries
- Structure:
- UniProt: P13799
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Tarek Msadek, Institut Pasteur, Paris, France
Your additional remarks
References
Reviews
Original Publications
