FatR

• Description: transcriptional repressor of the fatR-yrhJ operon
  
  

Gene name	fatR
Synonyms	yrhI, bscR
Essential	no
Product	transcriptional repressor of the fatR-yrhJ operon (TetR family)
Function	unknown
Gene expression levels in SubtiExpress: fatR
Interactions involving this protein in SubtInteract: FatR
MW, pI	22 kDa, 5.621
Gene length, protein length	582 bp, 194 aa
Immediate neighbours	yrhJ, yrhH
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

electron transport/ other, lipid metabolism/ other, transcription factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y), phosphoproteins

This gene is a member of the following regulons

FatR regulon, SigM regulon, SigW regulon, SigX regulon

The FatR regulon:

• fatR-yrhJ

The gene

Basic information

• Locus tag: BSU27170

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated by PtkA on Tyr-45, this results in displacement of FatR from the DNA PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • FatR-TkmA PubMed
  • FatR-PtkA PubMed

• Localization:

Database entries

• Structure:

• UniProt: O08335

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • fatR-yrhJ PubMed
  • yrhH-fatR-yrhJ PubMed

• Expression browser: fatR PubMed

• Sigma factor: SigM PubMed, SigW PubMed, SigX PubMed

• Regulation:
  • induced by unsaturated fatty acids (FatR) PubMed
  • expression is reduced in a SigV mutant PubMed

• Regulatory mechanism:
  • FatR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: