LiaR

• Description: two-component response regulator, regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin
  
  

Gene name	liaR
Synonyms	yvqC
Essential	no
Product	two-component response regulator
Function	regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin
Gene expression levels in SubtiExpress: liaR operon in response to bacitracin
Interactions involving this protein in SubtInteract: LiaR
MW, pI	22 kDa, 4.956
Gene length, protein length	633 bp, 211 aa
Immediate neighbours	gerAC, liaS
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics, phosphoproteins

This gene is a member of the following regulons

LiaR regulon

The gene

Basic information

• Locus tag: BSU33080

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on a Asp residue by LiaS

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • LiaS-LiaR

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O32197

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • liaI-liaH-liaG-liaF-liaS-liaR PubMed
  • liaG-liaF-liaS-liaR PubMed

• Expression browser: liaR PubMed

• Sigma factor:
  • liaI: SigA PubMed
  • liaG: SigA PubMed

• Regulation:
  • liaI: induced by bacitracin and rhamnolipids (LiaR) PubMed
  • liaI: repressed during logarithmic growth (AbrB) PubMed, indirect regulation by AbrB PubMed
  • liaG: constitutive

• Regulatory mechanism:
  • LiaR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage