DapI

• Description: N-acetyl-diaminopimelate deacetylase
  
  

Gene name	ykuR
Synonyms	dapL
Essential	yes PubMed
Product	N-acetyl-diaminopimelate deacetylase
Function	biosynthesis of lysine and peptidoglycan
Gene expression levels in SubtiExpress: ykuR
Metabolic function and regulation of this protein in SubtiPathways: Lys, Thr
MW, pI	41 kDa, 5.102
Gene length, protein length	1122 bp, 374 aa
Immediate neighbours	ykuQ, ykuS
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, biosynthesis/ acquisition of amino acids, essential genes

The gene

Basic information

• Locus tag: BSU14190

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: N-acetyl-LL-2,6-diaminoheptanedioate + H₂O = acetate + LL-2,6-diaminoheptanedioate (according to Swiss-Prot)

• Protein family: peptidase M20A family (according to Swiss-Prot)

• Paralogous protein(s): SndA, SndB, SndC

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34916

• KEGG entry: [2]

• E.C. number: 3.5.1.47

Expression and regulation

• Operon:

• Expression browser: ykuR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

The gene is annotated in KEGG as an ortholog of N-acetyldiaminopimelate deacetylase EC 3.5.1.47. In MetaCyc it is marked as “similar to hippurate hydrolase”. No EC annotation is available in Swiss-Prot. No literature/experimental evidence supporting the annotation is available. PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: