CwlC

• Description: N-acetylmuramoyl-L-alanine amidase
  
  

Gene name	cwlC
Synonyms
Essential	no
Product	N-acetylmuramoyl-L-alanine amidase
Function	mother cell lysis
Gene expression levels in SubtiExpress: cwlC
MW, pI	27 kDa, 5.939
Gene length, protein length	765 bp, 255 aa
Immediate neighbours	ymaB, spoVK
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall/ other, sporulation proteins

This gene is a member of the following regulons

SigK regulon

The gene

Basic information

• Locus tag: BSU17410

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides (according to Swiss-Prot)

• Protein family: N-acetylmuramoyl-L-alanine amidase 3 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: contains an amidase_3 domain (like CwlD, LytC, YqiI, YrvJ)

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • secreted (according to Swiss-Prot)

Database entries

• Structure: 1X60 (peptidoglycan binding domain)

• UniProt: Q06320

• KEGG entry: [3]

• E.C. number: 3.5.1.28

Expression and regulation

• Operon: cwlC PubMed

• Expression browser: cwlC PubMed

• Sigma factor: SigK PubMed

• Regulation:
  • expressed late during sporulation in the mother cell (SigK) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: