SpoIIGA

• Description: Pro-SigE protease
  
  

Gene name	spoIIGA
Synonyms
Essential	no
Product	Pro-SigE protease
Function	maturation of SigE
Gene expression levels in SubtiExpress: spoIIGA
Interactions involving this protein in SubtInteract: SpoIIGA
MW, pI	34 kDa, 8.552
Gene length, protein length	927 bp, 309 aa
Immediate neighbours	bpr, sigE
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

proteolysis, sigma factors and their control, sporulation/ other, membrane proteins

This gene is a member of the following regulons

SinR regulon, Spo0A regulon

The gene

Basic information

• Locus tag: BSU15310

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase U4 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:
  • SpoIIGA protease activity is stimulated by the interaction with SpoIIR in the intermembrane space between the forespore and the mother cell PubMed

• Interactions:
  • SpoIIGA-SigE (Processing) PubMed
  • SpoIIR-SpoIIGA PubMed

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P13801

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIIGA-sigE-sigG PubMed

• Expression browser: spoIIGA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • repression by SinR
  • Spo0A: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Additional reviews: PubMed

Original publications

Additional publications: PubMed