FtsA

• Description: cell-division protein, membrane anchor for FtsZ
  
  

Gene name	ftsA
Synonyms	spoIIN
Essential	yes PubMed
Product	cell-division protein
Function	formation of Z-ring
Gene expression levels in SubtiExpress: ftsA
Interactions involving this protein in SubtInteract: FtsA
MW, pI	47 kDa, 5.094
Gene length, protein length	1320 bp, 440 aa
Immediate neighbours	sbp, ftsZ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell division, essential genes, membrane proteins

This gene is a member of the following regulons

SigH regulon, WalR regulon

The gene

Basic information

• Locus tag: BSU15280

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ftsA/mreB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • FtsZ-FtsA

• Localization:
  • septal at the cell membrane PubMed
  • septal localization depends on the proton motive force PubMed

Database entries

• Structure:

• UniProt: P28264

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ftsA-ftsZ PubMed

• Expression browser: ftsA PubMed

• Sigma factor: SigA PubMed, SigH PubMed

• Regulation:
  • activated by WalR PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A787 ( ftsA::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248] [WorldCat.org] [DOI] (I p)