Difference between revisions of "PhoP"
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of [[phosphate metabolism]] <br/>(''[[phoA]], [[phoB]], [[phoD]], [[resA | resABCDE]], [[tagA]]-[[tagB]], [[tagD | tagDEF]], [[tuaA | tuaA-H]]'') | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of [[phosphate metabolism]] <br/>(''[[phoA]], [[phoB]], [[phoD]], [[resA | resABCDE]], [[tagA]]-[[tagB]], [[tagD | tagDEF]], [[tuaA | tuaA-H]]'') | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU29110 phoP] |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/PhoP PhoP] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/PhoP PhoP] | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[phoR]]'', ''[[mdh]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[phoR]]'', ''[[mdh]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU29110 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU29110 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU29110 Advanced_DNA] |
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Revision as of 13:34, 13 May 2013
- Description: two-component response regulator, regulation of phosphate metabolism
| Gene name | phoP |
| Synonyms | |
| Essential | no |
| Product | two-component response regulator |
| Function | regulation of phosphate metabolism (phoA, phoB, phoD, resABCDE, tagA-tagB, tagDEF, tuaA-H) |
| Gene expression levels in SubtiExpress: phoP | |
| Interactions involving this protein in SubtInteract: PhoP | |
| Metabolic function and regulation of this protein in SubtiPathways: Folate, Protein secretion | |
| MW, pI | 27 kDa, 5.068 |
| Gene length, protein length | 720 bp, 240 aa |
| Immediate neighbours | phoR, mdh |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
phosphate metabolism, transcription factors and their control, regulators of core metabolism, sporulation proteins, general stress proteins (controlled by SigB), membrane proteins, phosphoproteins
This gene is a member of the following regulons
CcpA regulon, PhoP regulon, SigB regulon, SigE regulon
The PhoP regulon
The gene
Basic information
- Locus tag: BSU29110
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylation by PhoR under conditions of phosphate limitation (stimulates DNA-binding activity)
- Cofactor(s):
- Effectors of protein activity: phosphorylation stimulates DNA-binding activity
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure: 1MVO (receiver domain)
- UniProt: P13792
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Marion Hulett, University of Illinois at Chicago, USA Homepage
Your additional remarks
References
Regulation of phoP-phoR expression
Biochemical analyses
Targets of PhoR
Additional publications: PubMed
Other original publications
Matthew Schau, Amr Eldakak, F Marion Hulett
Terminal oxidases are essential to bypass the requirement for ResD for full Pho induction in Bacillus subtilis.
J Bacteriol: 2004, 186(24);8424-32
[PubMed:15576792]
[WorldCat.org]
[DOI]
(P p)
C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672]
[WorldCat.org]
[DOI]
(P p)
