Difference between revisions of "Prs"
(→Categories containing this gene/protein) |
|||
Line 14: | Line 14: | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || phosphoribosylpyrophosphate synthesis <br/>(biosynthesis of histidine) | |style="background:#ABCDEF;" align="center"|'''Function''' || phosphoribosylpyrophosphate synthesis <br/>(biosynthesis of histidine) | ||
|- | |- | ||
− | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU00510 prs] |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/Prs Prs] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/Prs Prs] | ||
Line 26: | Line 26: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[gcaD]]'', ''[[ctc]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[gcaD]]'', ''[[ctc]]'' | ||
|- | |- | ||
− | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU00510 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU00510 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU00510 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:prs_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:prs_context.gif]] |
Revision as of 11:55, 13 May 2013
- Description: phosphoribosylpyrophosphate synthetase, universally conserved protein
Gene name | prs |
Synonyms | |
Essential | yes PubMed |
Product | phosphoribosylpyrophosphate synthetase |
Function | phosphoribosylpyrophosphate synthesis (biosynthesis of histidine) |
Gene expression levels in SubtiExpress: prs | |
Interactions involving this protein in SubtInteract: Prs | |
Metabolic function and regulation of this protein in SubtiPathways: Purine synthesis, Nucleotides (regulation), His, Murein recycling | |
MW, pI | 34 kDa, 5.895 |
Gene length, protein length | 951 bp, 317 aa |
Immediate neighbours | gcaD, ctc |
Sequences | Protein DNA Advanced_DNA |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, biosynthesis/ acquisition of nucleotides, essential genes, universally conserved proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00510
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
- Protein family: ribose-phosphate pyrophosphokinase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- subject to feedback inhibition by two end products of purine biosynthesis, adenosine 5'-diphosphate (ADP) and guanosine 5'-diphosphate (GDP) PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1IBS
- UniProt: P14193
- KEGG entry: [3]
- E.C. number: 2.7.6.1
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed