Difference between revisions of "DnaC"
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| + | ** stimulates [[DnaG]] primase activity {{PubMed|23563155}} | ||
* '''Protein family:''' DnaB subfamily (according to Swiss-Prot) | * '''Protein family:''' DnaB subfamily (according to Swiss-Prot) | ||
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** part of the [[primosome]]: [[DnaA]]-[[DnaG]]-[[DnaC]]-[[DnaI]]-[[DnaD]]-[[DnaB]] {{PubMed|22797751}} | ** part of the [[primosome]]: [[DnaA]]-[[DnaG]]-[[DnaC]]-[[DnaI]]-[[DnaD]]-[[DnaB]] {{PubMed|22797751}} | ||
** [[DnaX]]-[[DnaC]] {{PubMed|23525462}} | ** [[DnaX]]-[[DnaC]] {{PubMed|23525462}} | ||
| + | ** [[DnaE]]-[[DnaC]] {{PubMed|23563155}} | ||
| + | ** [[DnaG]]-[[DnaC]] {{PubMed|23563155}} | ||
* '''[[Localization]]:''' Cytoplasm (Homogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed] | * '''[[Localization]]:''' Cytoplasm (Homogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed] | ||
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<pubmed> 22797751</pubmed> | <pubmed> 22797751</pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>10844689,12718886,11250911, 20122408,16479537, 10844689 19744498 19968790 12060778 23525462 </pubmed> | + | <pubmed>10844689,12718886,11250911, 20122408,16479537, 10844689 19744498 19968790 12060778 23525462 23563155</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:24, 15 April 2013
- Description: replicative DNA helicase, part of the replisome
| Gene name | dnaC |
| Synonyms | |
| Essential | yes PubMed |
| Product | replicative DNA helicase |
| Function | DNA replication |
| Gene expression levels in SubtiExpress: dnaC | |
| Interactions involving this protein in SubtInteract: DnaC | |
| MW, pI | 50 kDa, 4.548 |
| Gene length, protein length | 1362 bp, 454 aa |
| Immediate neighbours | yycE, yycD |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40440
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Protein family: DnaB subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: Cytoplasm (Homogeneous) PubMed
Database entries
- UniProt: P37469
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: dnaC (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Geoffrey S Briggs, Wiep Klaas Smits, Panos Soultanas
Chromosomal replication initiation machinery of low-G+C-content Firmicutes.
J Bacteriol: 2012, 194(19);5162-70
[PubMed:22797751]
[WorldCat.org]
[DOI]
(I p)
Original publications
