Difference between revisions of "MleA"
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= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| − | + | {{SubtiWiki regulon|[[AnsR regulon]]}}, | |
| + | {{SubtiWiki regulon|[[CcpA regulon]]}} | ||
=The gene= | =The gene= | ||
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=== Additional information=== | === Additional information=== | ||
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* '''Operon:''' | * '''Operon:''' | ||
| + | ** ''[[ansA]]-[[ansB]]-[[mleN]]-[[mleA]]'' {{PubMed|22383849}} | ||
| + | ** ''[[mleN]]-[[mleA]]'' {{PubMed|22383849}} | ||
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mleA_2451463_2452782_-1 mleA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mleA_2451463_2452782_-1 mleA] {{PubMed|22383849}} | ||
* '''Sigma factor:''' | * '''Sigma factor:''' | ||
| + | ** ''[[mleN]]'': [[SigA]] {{PubMed|22900538}} | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** repressed by glucose ([[CcpA]]) {{PubMed|22900538}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[CcpA]]: transcription repression {{PubMed|22900538}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
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=References= | =References= | ||
| − | <pubmed> 16788182 </pubmed> | + | <pubmed> 16788182 22383849 22900538</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:07, 23 August 2012
- Description: malic enzyme
| Gene name | mleA |
| Synonyms | yqkJ |
| Essential | no |
| Product | NAD-dependent malate dehydrogenase |
| Function | malate utilization |
| Gene expression levels in SubtiExpress: mleA | |
| Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism | |
| MW, pI | 45 kDa, 4.895 |
| Gene length, protein length | 1317 bp, 439 aa |
| Immediate neighbours | yqkK, mleN |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
utilization of specific carbon sources
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU23550
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: (S)-malate + NAD+ = pyruvate + CO2 + NADH (according to Swiss-Prot) malate --> pyruvate
- Protein family: malic enzymes family (according to Swiss-Prot)
- Paralogous protein(s): YtsJ
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P54572
- KEGG entry: [2]
- E.C. number: 1.1.1.38
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant: GP1136 (cat) available in Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
