Difference between revisions of "KinC"

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* '''Description:''' [[two-component systems|two-component]] sensor kinase, phosphorylates [[Spo0F]] and [[Spo0A]], part of the [[phosphorelay]], governs expression of genes involved in [[biofilm formation]] <br/><br/>
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* '''Description:''' [[two-component systems|two-component]] sensor kinase, phosphorylates [[Spo0F]] and [[Spo0A]] in response to the presence of surfactin, part of the [[phosphorelay]], governs expression of genes involved in [[biofilm formation]] <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] sensor kinase
 
|style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] sensor kinase
 
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|-
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|style="background:#ABCDEF;" align="center"|'''Function''' || initiation of sporulation
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|style="background:#ABCDEF;" align="center"|'''Function''' || initiation of [[sporulation]]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU14490 kinC]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU14490 kinC]
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{{SubtiWiki category|[[transcription factors and their control]]}},
 
{{SubtiWiki category|[[transcription factors and their control]]}},
 
{{SubtiWiki category|[[phosphorelay]]}},
 
{{SubtiWiki category|[[phosphorelay]]}},
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{{SubtiWiki category|[[biofilm formation]]}},
 
{{SubtiWiki category|[[membrane proteins]]}},
 
{{SubtiWiki category|[[membrane proteins]]}},
 
{{SubtiWiki category|[[phosphoproteins]]}}
 
{{SubtiWiki category|[[phosphoproteins]]}}
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
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** defective in [[biofilm formation]] {{PubMed|22882210}}
  
 
=== Database entries ===
 
=== Database entries ===
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=== Additional information===
 
=== Additional information===
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** autophosphorylation, phosphorylation of [[Spo0F]] as part of the [[phosphorelay]], but also direct phosphorylation of [[Spo0A]] {{PubMed|19114652}}
 
** autophosphorylation, phosphorylation of [[Spo0F]] as part of the [[phosphorelay]], but also direct phosphorylation of [[Spo0A]] {{PubMed|19114652}}
 
** mainly active in the younger, outer regions of a colony (with [[KinD]]) {{PubMed|21097618}}  
 
** mainly active in the younger, outer regions of a colony (with [[KinD]]) {{PubMed|21097618}}  
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** phosphorylates [[Spo0A]] in response to the presence of surfactin {{PubMed|22882210}}
  
 
* '''Protein family:'''
 
* '''Protein family:'''
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** cell membrane (Heterogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
 
** cell membrane (Heterogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
 
** co-localizes with [[FloT]] in discrete foci in the membrane {{PubMed|20713508}}
 
** co-localizes with [[FloT]] in discrete foci in the membrane {{PubMed|20713508}}
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** the localization of [[KinC]] in membrane microdomains depends on [[FloA]] and [[FloT]]  {{PubMed|22882210}}
  
 
=== Database entries ===
 
=== Database entries ===
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=References=
 
=References=
  
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<pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 </pubmed>
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<pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 12:58, 14 August 2012

Gene name kinC
Synonyms ssb
Essential no
Product two-component sensor kinase
Function initiation of sporulation
Gene expression levels in SubtiExpress: kinC
Interactions involving this protein in SubtInteract: KinC
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 48 kDa, 6.225
Gene length, protein length 1284 bp, 428 aa
Immediate neighbours abh, ykqA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
KinC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
KinC expression.png



















Categories containing this gene/protein

protein modification, transcription factors and their control, phosphorelay, biofilm formation, membrane proteins, phosphoproteins

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

  • Locus tag: BSU14490

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • autophosphorylation, phosphorylation of Spo0F as part of the phosphorelay, but also direct phosphorylation of Spo0A PubMed
    • mainly active in the younger, outer regions of a colony (with KinD) PubMed
    • phosphorylates Spo0A in response to the presence of surfactin PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
  • Modification: autophosphorylation on a His residue
  • Cofactor(s):
  • Effectors of protein activity:
    • activity is triggered by potassium leakage PubMed
    • activity is triggered by polyisoprenoid lipids formed by YisP PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: kinC (according to DBTBS)
  • Regulation:
    • expressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

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