Difference between revisions of "FloT"
Line 37: | Line 37: | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
− | |||
<br/><br/> | <br/><br/> | ||
Line 62: | Line 61: | ||
** a ''[[floT]] [[floA]]'' double mutant does not induce [[KinC]]-dependent biofilm formation upon addition of surfactin {{PubMed|20713508}} | ** a ''[[floT]] [[floA]]'' double mutant does not induce [[KinC]]-dependent biofilm formation upon addition of surfactin {{PubMed|20713508}} | ||
** a ''[[floT]] [[floA]]'' double mutant has a strong synthetic defect in motility, cell morphology, and transformation efficiency {{PubMed|22753055}} | ** a ''[[floT]] [[floA]]'' double mutant has a strong synthetic defect in motility, cell morphology, and transformation efficiency {{PubMed|22753055}} | ||
+ | ** a ''[[floT]] [[floA]]'' double mutant has a [[sporulation]] defect, due to the lack of [[FtsH]] {{PubMed|22882210}} | ||
+ | |||
=== Database entries === | === Database entries === | ||
Line 96: | Line 97: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
** [[YuaF]]-[[FloT]] {{PubMed|22753055}} | ** [[YuaF]]-[[FloT]] {{PubMed|22753055}} | ||
+ | ** [[FloT]]-[[FtsH]] {{PubMed|22882210}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
Line 149: | Line 151: | ||
=References= | =References= | ||
'''Additional publications:''' {{PubMed|22178969}} | '''Additional publications:''' {{PubMed|22178969}} | ||
− | <pubmed>9987136,22753055, 12107147, 18763711, 19383680 20713508 </pubmed> | + | <pubmed>9987136,22753055, 12107147, 18763711, 19383680 20713508 22882210</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] |
Revision as of 10:43, 14 August 2012
- Description: similar to flotillin 1, orchestration of physiological processes in lipid microdomains, involved in the control of membrane fluidity, confers (together with YuaF) resistance to cefuroxime
Gene name | floT |
Synonyms | yuaG, yuaH |
Essential | no |
Product | bacterial flotillin-like protein |
Function | involved in the control of membrane fluidity |
Gene expression levels in SubtiExpress: floT | |
Interactions involving this protein in SubtInteract: FloT | |
MW, pI | 55 kDa, 5.135 |
Gene length, protein length | 1527 bp, 509 aa |
Immediate neighbours | yuaI, yuaF |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
biofilm formation, membrane dynamics, membrane proteins sporulation/ other, cell envelope stress proteins (controlled by SigM, V, W, X, Y)
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31010
Phenotypes of a mutant
- delayed onset of sporulation, reduced sporulation frequency
- defect in motility PubMed
- a floT floA double mutant does not induce KinC-dependent biofilm formation upon addition of surfactin PubMed
- a floT floA double mutant has a strong synthetic defect in motility, cell morphology, and transformation efficiency PubMed
- a floT floA double mutant has a sporulation defect, due to the lack of FtsH PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O32076
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed