Difference between revisions of "YuaF"
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| − | * '''Description:''' role in maintaining membrane integrity during conditions of cellular stress, confers (together with [[FloT]]) resistance to cefuroxime <br/><br/> | + | * '''Description:''' NfeD2, role in maintaining membrane integrity during conditions of cellular stress, confers (together with [[FloT]]) resistance to cefuroxime <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || NfeD family protein | + | |style="background:#ABCDEF;" align="center"| '''Product''' || NfeD family protein NfeD2 |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || involved in the control of membrane fluidity | |style="background:#ABCDEF;" align="center"|'''Function''' || involved in the control of membrane fluidity | ||
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** [[SigW]]-dependent expression of ''[[fabF]]'' and the ''[[yuaF]]-[[floT]]-[[yuaI]]'' operon result in reduced membrane fluidity {{PubMed|21542858,22178969}} | ** [[SigW]]-dependent expression of ''[[fabF]]'' and the ''[[yuaF]]-[[floT]]-[[yuaI]]'' operon result in reduced membrane fluidity {{PubMed|21542858,22178969}} | ||
| − | * '''Protein family:''' NfeD family | + | * '''Protein family:''' NfeD family (with [[YqeZ]]) |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
Revision as of 16:55, 6 July 2012
- Description: NfeD2, role in maintaining membrane integrity during conditions of cellular stress, confers (together with FloT) resistance to cefuroxime
| Gene name | yuaF |
| Synonyms | |
| Essential | no |
| Product | NfeD family protein NfeD2 |
| Function | involved in the control of membrane fluidity |
| Interactions involving this protein in SubtInteract: YuaF | |
| MW, pI | 18 kDa, 4.042 |
| Gene length, protein length | 522 bp, 174 aa |
| Immediate neighbours | floT, yuaE |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
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Contents
Categories containing this gene/protein
membrane dynamics, cell envelope stress proteins (controlled by SigM, V, W, X, Y)
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31020
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: NfeD family (with YqeZ)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 2K14
- UniProt: O32077
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Christina A Walker, Markus Hinderhofer, David J Witte, Winfried Boos, Heiko M Möller
Solution structure of the soluble domain of the NfeD protein YuaF from Bacillus subtilis.
J Biomol NMR: 2008, 42(1);69-76
[PubMed:18696230]
[WorldCat.org]
[DOI]
(P p)
X Huang, A Gaballa, M Cao, J D Helmann
Identification of target promoters for the Bacillus subtilis extracytoplasmic function sigma factor, sigma W.
Mol Microbiol: 1999, 31(1);361-71
[PubMed:9987136]
[WorldCat.org]
[DOI]
(P p)
