RsbRB

• Description: probably part of the stressosome
  
  

Gene name	rsbRB
Synonyms	ispU, ykoB
Essential	no
Product	RsbR paralog
Function	control of SigB activity
Interactions involving this protein in SubtInteract: RsbRB
MW, pI	32 kDa, 4.788
Gene length, protein length	831 bp, 277 aa
Immediate neighbours	ispA, thiX
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

sigma factors and their control, phosphoproteins

The gene

Basic information

• Locus tag: BSU13200

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • negative regulator of YtvA-dependent light activation of the SigB stress response PubMed

• Protein family:

• Paralogous protein(s): RsbR, RsbRC, RsbRD, YtvA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Thr-186 and probably also on Thr-220 by RsbT PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RsbRB-RsbT PubMed
  • component of the stressosome

• Localization:

Database entries

• Structure:

• UniProt: O34860

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation: constitutively expressed PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Adam Reeves, Luis Martinez, William Haldenwang
Expression of, and in vivo stressosome formation by, single members of the RsbR protein family in Bacillus subtilis.
Microbiology (Reading): 2010, 156(Pt 4);990-998
[PubMed:20019076] [WorldCat.org] [DOI] (I p)

Christine Eymann, Dörte Becher, Jörg Bernhardt, Katrin Gronau, Anja Klutzny, Michael Hecker
Dynamics of protein phosphorylation on Ser/Thr/Tyr in Bacillus subtilis.
Proteomics: 2007, 7(19);3509-26
[PubMed:17726680] [WorldCat.org] [DOI] (P p)

Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307] [WorldCat.org] [DOI] (P p)

Tae-Jong Kim, Tatiana A Gaidenko, Chester W Price
A multicomponent protein complex mediates environmental stress signaling in Bacillus subtilis.
J Mol Biol: 2004, 341(1);135-50
[PubMed:15312768] [WorldCat.org] [DOI] (P p)